Active substances: Ciprofloxacin
Type the full drug name in the search box above. Don't know the drug name? Combination of compound 1 with subinhibitory concentrations of ciprofloxacin renders a wild-type more susceptible and a NorA overexpresser S.
MRSA, antibiotic resistance, antibiotics, natural compounds Introduction Active efflux makes bacteria resistant towards antibiotics by reducing the intracellular concentration to an ineffective level.
The multidrug efflux transporter NorA of Staphylococcus aureus confers multidrug resistance MDR to a broad spectrum of compounds, including fluoroquinolones, quaternary ammonium compounds, reserpine, verapamil and the dyes ethidium bromide, rhodamine and acridines.
In half of bloodstream isolates of S. All three efflux pumps were overexpressed in more than half of these.
Combination of an antibiotic with an efflux pump inhibitor EPI would be expected to re-establish susceptibility of the bacteria to antibiotics that at present cannot be used any longer.
Combination therapy might even synergistically increase the susceptibility of the bacteria.
Several plant-derived compounds, including the alkaloid reserpine from Rauvolfia vomitoria, the terpene carnosic acid from Rosmarinus officinalis and the diterpene totarol from Chamaecyparis nootkatensis, inhibit NorA-induced ethidium bromide efflux from a NorA overexpresser.
They were done in electrospray ionization ESI -positive mode. Plant material P. The dried plant material was stored in paper bags until use. The combined extracts were concentrated in vacuo to give 61. Do not allow the liquid medicine to freeze.
Throw away any unused liquid after 14 days. See also: Ciprofloxacin dosage information in more detail What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose? What should I avoid while taking ciprofloxacin?Abstract Objectives To isolate a plant-derived compound with efflux inhibitory activity towards the NorA transporter of Staphylococcus aureus.
Do not give this medicine to a child without medical advice. It is not known whether this medicine will harm an unborn baby.