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Recommendations for these new measures were originally made by EMA's Pharmacovigilance Risk Assessment Committee PRAC, which confirmed a previously known risk of QT interval prolongation and torsades de pointes, alterations in the electrical activity of the heart that can lead to abnormal heart rhythms and cardiac arrest stopping of the heart.
Having assessed the available evidence, including published studies and data from regular safety monitoring, the PRAC concluded that the risk did not differ between indications and that such events are most likely to occur in patients who have risk factors.
The PRAC therefore recommended that the risk be managed by restricting hydroxyzine use in those most at risk of heart rhythm problems and reducing exposure to the medicine.
In particular, the product information of hydroxyzine-containing medicines will be updated with new dosing recommendations and warnings on use in patients who have risk factors for heart rhythm disturbances or who are taking certain other medicines.
Expand section Collapse section Information to patients Medicines containing the antihistamine hydroxyzine are available in most EU countries.
There is a small risk of altered electrical activity of the heart when taking these medicines, which can lead to abnormal heart rhythm or even cause the heart to stop cardiac arrest.
The risk is mostly seen in patients who already have heart rhythm problems or have risk factors for these problems. To reduce the risk to a minimum, new measures have been agreed for these medicines to ensure they are used for as short a time as possible at the lowest effective dose, and that their use is avoided in those at higher risk.
It also acts as an antihistamine that reduces the natural chemical histamine in the body As to the good sales tax people in Tennessee, buy atarax in uk I am no longer selling anything. It is a leading international prescription service that provides both generic and branded forms of Hydroxyzine Buy Atarax In The Uk!
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