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The patient discusse in the present study did not present with Raynaud syndrome, erythema multiforme-like palmar-plantar involvement or bullous lupus erythematosus lesions, as other cases of Rowell syndrome reported in the literature have 11.
The present case was not preceded by signs of respiratory infection or herpes simplex virus type I or II lesions, and serology for herpes infection was negative.
The first SCLE episode was triggered by terbinafine, for which adverse effects have previously been reported in the literature 25. However, after a 4-year-long interval, the SCLE reoccurred with the erythema multiforme-like lesions, this time shortly after the introduction of treatment to eradicate H.
The cases of Rowell syndrome reported in the literature had a good prognosis with complete remission of skin lesions within 1 year.
Furthermore, in the reported case, the Rowell syndrome was drug-induced. In addition, the typical Rowel syndrome skin lesions, the patient continued to present with high levels of anti-Ro antibodies, rheumatoid factor and total antinuclear antibodies, though at much lower levels compared with at onset.
The high levels of these antibodies whilst under therapy highlights the requirement for surveillance in Rowell syndrome, in addition to the long-term and unpredictable course of the disease.
Different therapies studied for Rowell syndrome have produced variable results 4, 11, 12, highlighting the importance of developing novel and more effective treatments. Diagn Pathol.
Klin Lab. Case Rep Rheumatol. Indian Dermatol Online J. Indian J Dermatol.
Int J Sci Res. A syndrome with characteristic immunological abnormalities. Arch Dermatol. Can J Dermatol. Brit J Dermatol.